--- EXPERIMENT NOTES




 --- EXPERIMENT PROPERTIES

#Fri Nov 03 22:34:30 WET 2017
codeml.models=0 1 2 3 7 8
mrbayes.mpich=
mrbayes.ngen=1000000
tcoffee.alignMethod=MUSCLE
tcoffee.params=
tcoffee.maxSeqs=0
codeml.bin=codeml
mrbayes.tburnin=2500
codeml.dir=
input.sequences=
mrbayes.pburnin=2500
mrbayes.bin=mb_adops
tcoffee.bin=t_coffee_ADOPS
mrbayes.dir=/usr/bin/
tcoffee.dir=
tcoffee.minScore=3
input.fasta=
input.names=
mrbayes.params=
codeml.params=



 --- PSRF SUMMARY

      Estimated marginal likelihoods for runs sampled in files
"/opt/ADOPS1/revmuscle/S25falta/batch/allfiles/mrbayes/input.fasta.fasta.mrb.run1.p" and "/opt/ADOPS1/revmuscle/S25falta/batch/allfiles/mrbayes/input.fasta.fasta.mrb.run2.p":
(Use the harmonic mean for Bayes factor comparisons of models)

(Values are saved to the file /opt/ADOPS1/revmuscle/S25falta/batch/allfiles/mrbayes/input.fasta.fasta.mrb.lstat)

Run   Arithmetic mean   Harmonic mean
--------------------------------------
1      -7042.75         -7064.12
2      -7043.10         -7065.66
--------------------------------------
TOTAL    -7042.91         -7065.16
--------------------------------------


Model parameter summaries over the runs sampled in files
"/opt/ADOPS1/revmuscle/S25falta/batch/allfiles/mrbayes/input.fasta.fasta.mrb.run1.p" and "/opt/ADOPS1/revmuscle/S25falta/batch/allfiles/mrbayes/input.fasta.fasta.mrb.run2.p":
Summaries are based on a total of 3002 samples from 2 runs.
Each run produced 2001 samples of which 1501 samples were included.
Parameter summaries saved to file "/opt/ADOPS1/revmuscle/S25falta/batch/allfiles/mrbayes/input.fasta.fasta.mrb.pstat".

95% HPD Interval
--------------------
Parameter         Mean      Variance     Lower       Upper       Median    min ESS*  avg ESS    PSRF+
------------------------------------------------------------------------------------------------------
TL{all}         1.331016    0.003233    1.226320    1.443893    1.329765   1298.93   1395.16    1.000
r(A<->C){all}   0.117474    0.000158    0.092901    0.142302    0.117121    847.48    939.43    1.000
r(A<->G){all}   0.297363    0.000379    0.258844    0.334796    0.297474    750.19    872.46    1.000
r(A<->T){all}   0.078046    0.000068    0.062948    0.095105    0.077873   1153.77   1174.83    1.000
r(C<->G){all}   0.163156    0.000263    0.134256    0.196607    0.162620    663.76    853.84    1.000
r(C<->T){all}   0.260710    0.000330    0.225974    0.295316    0.260394    906.07    911.85    1.001
r(G<->T){all}   0.083251    0.000089    0.064139    0.100506    0.082960    992.18   1020.01    1.000
pi(A){all}      0.301392    0.000122    0.278863    0.322302    0.301282    856.66    920.63    1.001
pi(C){all}      0.175863    0.000081    0.158631    0.193971    0.175793   1076.44   1093.34    1.000
pi(G){all}      0.189692    0.000085    0.171870    0.207324    0.189621    989.99   1044.81    1.001
pi(T){all}      0.333053    0.000128    0.310984    0.355661    0.332719    776.17    877.57    1.001
alpha{1,2}      0.750422    0.013312    0.546611    0.979599    0.735035   1109.70   1259.81    1.000
alpha{3}        1.744012    0.198230    1.012189    2.626343    1.665629   1147.07   1262.52    1.000
pinvar{all}     0.045311    0.001303    0.000011    0.116443    0.036826   1088.31   1180.89    1.001
------------------------------------------------------------------------------------------------------
* Convergence diagnostic (ESS = Estimated Sample Size); min and avg values
correspond to minimal and average ESS among runs.
ESS value below 100 may indicate that the parameter is undersampled.
+ Convergence diagnostic (PSRF = Potential Scale Reduction Factor; Gelman
and Rubin, 1992) should approach 1.0 as runs converge.


Setting sumt conformat to Simple



 --- CODEML SUMMARY

Model 1: NearlyNeutral	-2227.921827
Model 2: PositiveSelection	-2204.837837
Model 0: one-ratio	-2280.446087
Model 3: discrete	-2204.797246
Model 7: beta	-2231.552526
Model 8: beta&w>1	-2206.079964


Model 0 vs 1	105.04851999999937

Model 2 vs 1	46.16798000000017

Additional information for M1 vs M2:
Naive Empirical Bayes (NEB) analysis
Positively selected sites (*: P>95%; **: P>99%)
(amino acids refer to 1st sequence: S25_SFBB1)

            Pr(w>1)     post mean +- SE for w

    19 Q      0.935         4.532
    36 T      0.866         4.269
    51 E      0.981*        4.704
    54 C      1.000**       4.776
    70 T      1.000**       4.776
    72 E      0.988*        4.731
   100 K      0.867         4.275
   117 C      0.973*        4.673

Bayes Empirical Bayes (BEB) analysis (Yang, Wong & Nielsen 2005. Mol. Biol. Evol. 22:1107-1118)
Positively selected sites (*: P>95%; **: P>99%)
(amino acids refer to 1st sequence: S25_SFBB1)

            Pr(w>1)     post mean +- SE for w

    19 Q      0.922         4.647 +- 1.324
    36 T      0.826         4.219 +- 1.644
    51 E      0.971*        4.830 +- 1.047
    54 C      1.000**       4.959 +- 0.836
    70 T      1.000**       4.958 +- 0.837
    72 E      0.985*        4.901 +- 0.956
   100 K      0.822         4.194 +- 1.646
   117 C      0.948         4.716 +- 1.163


Model 8 vs 7	50.94512399999985

Additional information for M7 vs M8:
Naive Empirical Bayes (NEB) analysis
Positively selected sites (*: P>95%; **: P>99%)
(amino acids refer to 1st sequence: S25_SFBB1)

            Pr(w>1)     post mean +- SE for w

    19 Q      0.954*        4.173
    36 T      0.909         4.019
    51 E      0.988*        4.289
    54 C      1.000**       4.329
    70 T      1.000**       4.328
    72 E      0.992**       4.301
   100 K      0.913         4.033
   117 C      0.985*        4.277

Bayes Empirical Bayes (BEB) analysis (Yang, Wong & Nielsen 2005. Mol. Biol. Evol. 22:1107-1118)
Positively selected sites (*: P>95%; **: P>99%)
(amino acids refer to 1st sequence: S25_SFBB1)

            Pr(w>1)     post mean +- SE for w

    19 Q      0.946         4.221 +- 1.112
    36 T      0.882         3.962 +- 1.339
    51 E      0.984*        4.354 +- 0.904
    54 C      1.000**       4.418 +- 0.800
    70 T      1.000**       4.418 +- 0.801
    72 E      0.990**       4.384 +- 0.867
   100 K      0.884         3.960 +- 1.329
   117 C      0.973*        4.306 +- 0.955

>C1
LSSSTCILLNRCQNHVFPDRSWKPEVFWSLINLSIDSDDHNLHYDVEDLN
IPCPLEGHDFVEIGGYCNGIVCVLAWKTLHWIYVILCNPATGEFRQLPHS
CLLQPSRSRRKFELNTISTLLGFGYDCKAKEYKVVQVIENCEYSDAEQYD
YHRIALPHTAEVYTTTANSWREIKIDISSETYCYTCSVYLNGFCYWIATD
EEDFILSFDLGDEIFHRIQLPSRRDSDFKFSNLFLCNKSIASFGYCCNPS
DEDSTooooooooooooooooooooooooooooooooooooooooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
o
>C2
MNESETPGDRVVEILSKLWPKSLMRFKCIRKSWCTLINSPSFVVKHLNNS
MDNKLSSSTCILVNRSQPHIFPDQNWKQEIFWSKINISIDSDEHNLHYDV
VDLNIPFPLEDHDFVQIHGYCSGIVCVIVGKHFLLCNPATREFKQLPDSC
LLLPTAEGKFELDTTFEALGFGFDCKAKEYKVVQIIENCEYSDDEQTFYH
CTTLPHTAEVYTTAANSWKEIKIDISSKTYSWSCSVYLKGFCYWYATDDE
EYVLSFDLGDETFHRIQLPSRGVSGFTFFYIFLCNGSLASFCSRYDGSGD
SQSCEIWVMGDYGKVKSSWTKLLTIESLQGIEKPLTFWKSDELLMLASNG
KATSYNSSSGNLKYVHIPPILNKVVDFQALIYVESIVSLKoooooooooo
o
>C3
KSLMRFKCIHKSWFSLINSLSFVGKHLSNFVDKKLSSSTCILLNRSHAHI
FPDQSWKQEVFWSMINFSIDNDENNLHYDVEDLNIPFPLNDHDFVLIFGY
CNGIVCVEAGKNVLLCNPATREFRQLPDSCLLLPSPPEGKFELETSFQAL
GFGYDCNAKEYKVLRIIENCEYSDEERTFYHRIALPHTAELYTATANSWK
EIKIDISSATYSCSRSVFLKGFCYWYATDGEEYVLSFDLGDDTFHIIQLP
PRRESGFRFYYIFLRNESLASFCSRYDRSEDSESCEIWVMDDYDRVKSSW
TKLLTIGPLQGIKKPLTFWKSDEVLMLDSDGRATSYNSNTRNLKYLHIPP
ILKRVVDFEVLIYVKSoooooooooooooooooooooooooooooooooo
o
>C4
ETPEDKVVEILSRLQPKSLMRFKCIHKSWCTLINSPSFVAKHLNNSMDNK
LSSSTCILLNRSQAHIFPDQSWKQEVFWSTINLSIDSDEHNLHYDVEDLI
IPFPLEDHDFVLIFGYCNGIICVDAGKNVLLCNPATREFRQLPDSCLLLP
PPKGKFELETTFQALGFGYDCNSKEYKVVRIIENCEYSDDEQTFHHRIAL
PHTAEVYTTAANSWKEIKIDISSQTYHCSCSVYLNGFCYWFASDSEEYIL
SFYLGDETFHIIQLPSRRESGFTFDYIFLRNESLASFCSPYNPSEDSKLF
EIWVMDDYDGVKSSWTKLLTVGPFKGIEYPLTLWKCDELLMLASDGRATS
YNSSTGNLKYLHIPPILNKVVDFEGLIYVKSIVPoooooooooooooooo
o
>C5
MSQVRESETLEDRVVETLSRLPPKSLIRFKCIRKSWCTLINNPSFVAKHL
NNSMDNKLSSSTCILLSRSQAHVFPDNSWKPEVFWSLINLSIDSDEHNLH
YDVEDLNIPFPLEGHDFVQIEGYCNGIVCVIAGTSLYLINVLLCNPATGK
FRQLPPSCLLLPSRPKGKFELESIFGGLGFGYDCKAKEYKVVQIIENCEY
SDDQQYYYHRIALPHTAEVYTMAANSWREIKIDLSSETFHCSYSVYLKGF
CYWLATNGEKYILSFDFGDKVFHRIQLPSRRESDFEFSNLFLCNNSMASF
FSCCDPSDEDSTLCEIWVoooooooooooooooooooooooooooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
o
>C6
MWNKIFEMSQARESETLEDKVVQILSRLPPKSLMRFKCTRKSWCTLINSS
SFVAKHLSNSIDNKLSSSTCILLNRSKMPVFLDKSWKYEILWSMIYLSID
SDEHNHHYDVEDLNIPFPLEDHHPVQIHGYCNGIICVIAGKTVIILCNPG
TREFRQLPDSCLLVPLPKEKFQLETIFGGLGFGYDCKAKEYKVVQIIENC
EYSNDERTFYHSIPLPHTAEVYTIAANSWKEIKIDISTKTYPSSCSVYLK
GFCYWFASDGEECILSFDLGDEIFHRIQLPSRRESSFKFYDIFLYNESIT
SYCSHYDPSDDSKLFEIWVMDDYDGSKSSWTKLLTVGPFKGIEYPLALWK
CDELLMLASNGRAISYNSSTGNLKYLHIPPIINEVIDFEALSYVESIVPI
K
>C7
KCIRKSWCTLINSPRFVAKHLNNSTDNKLSSSTRILLHRSQMPIFPCDSW
KREFFWSMINLSIDSDESNLHYDVEDLTNIPLLQWEDHHEVEIHGYCNGI
VCVTVGEYFFLCNPATGEFSQLPNSRLLLPLPGGKGKFGLETTVKGLGFG
YDCKAKEYKVVRIIENYDCEYSDGEETYIKHTALPHTAEVYTTTANSWKE
IQINISSKILSFYSYPYSCSLYLKGFCYWLSSDDEEYVFSFDLGDEIFDR
IELPSRRESGFKLDGIFLYNESITYYCTSYEECSRLFEIWVMDNYDGVKS
SWTKoooooooooooooooooooooooooooooooooooooooooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
o
>C8
MSLVRESEIPEDRVVEILPRLSPKSLLRFKCIRKSWCTLINSPSFVAKQL
SNSVDNKFSSSTCILLNRSQTHVFPDNSWKQEVFWSMINLSlDSDEHNLH
YDVEDLNIPFPLEDHDYVLILGYCNGIVCVTAGKNILLCNPTTREFMRLP
SSCLLLPSRPKGKFELETVFRALGFGYDCKAKEYKVVQIIENSEYSDDER
TYYHRIPLPHTAEVYTTAANSWREIKIDISTKTYSCSCQVYLKGFCYWYA
TDAEEYILSFDLGDEIFHRIQLPSRRESGFKFYYIFLCNESIASFCSCYo
oooooooooooooooooooooooooooooooooooooooooooooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
o
>C9
KEYKVVQIIENCEYSDDQQYYYHRIALPHTAEVYTMAANSWRVIKIDISS
ETYHYSSSVYLNGFFYWFAIDGEKYVLSFDLGDEIFHRIQLPSRKESDFE
FSNIFLCNKSIASFCSRCDPSDEDSTLCEIWVMDDYDGVDRSWTKLLTFG
PLKDIENPFTFWKTDELLMVAAGGRATTYNFSTGNLNYLHIPPILNEVRD
FEALIYVESIVPVKoooooooooooooooooooooooooooooooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
o
>C10
MTQVRESETPEDRVAEILSRLPPKSLMRFKCIRKSWYKVIKNPSFMAKHL
SKNSVDNKFSSSTCILLHRSQMPVFPDRSWKREYFWSMINLSHDSDKHNL
YYDVEDLNIQFPLEDHDHVSIHGYCNGIVCLIVGKNAVLYNPATRELKQL
PDSCLLLPSPPEGKFKLESTFQGMGFGYDSQAKEYKVVKIIENCEYSDDM
RTFSHRIALPHTAEVYVMTTNSWRVIEIEISSDTYNCSCSVYLKGFCYWF
ASDDEEYILSFDLGDEIFHRIQLPYRKESGFLFYNLFLYNESIASFCSHY
DKSDNSGILEILEIWVMDDCDGVKSSWTKLLTLGPFKDNENLLTFWKSDE
LLMVTSDKKTISYNSSTGNLKYIHIPPIINKVoooooooooooooooooo
o
>C11
MSLVRESEIPEDRVVEILPRLSPKSLLRFKCIrKSWCTLINSPSFVAKHL
NNSVDNKRSSSTCILLNRSQFHIFPDQSWKREVLWSMINLSSDSNVHNLH
YDVKPLNIPFSRDDHNPVQIHGYCNGIVCLIEGDNVLLCNPSTREFRLLP
NSCLLVPHPEGKFQLETTFHGMGFGYDCKANEYKVVQIVENCEYSDDEQT
YQHCIAYPYTAEVYTTAANFWKEIKIDISSSTHPYPFSVYLKGFCYWFAT
DGEECILSFDLGDEIFHRIQLPSKIESGFNFCGLFLYNESITSYCCRYDP
SEDSKLFEIWVMDooooooooooooooooooooooooooooooooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
o
>C12
MSQVSESETPEDKVVEILSKLPPKSLMRFKCIRKSWCTIINSPSFVAKHL
SNSVDNKFSSSTCILLNRSQVHVFPDKSWKHEVLWSMIKFFNDRISRTLY
YDVEDLNIPFPRDDHQHVLIHGYCNGIVCVISGKNILLCNPATREFRQLP
DSFLVLPSPLSGKFELETDLGGLGFGYDCRAKDYKVVRIIENCEYSDDER
TYYNRIPLPHTSEVYTMATNSWKEIKIDISRKTYPCSCSVYLKGFCYWFT
RDGEEFILSFDLGDERFHRIQLPSRRESGLEFYYIFLCNESIASFCSLYD
RSEDSKLCEIWVMDDYDGVKSSWTKLLVAGPFKGIEKPLTLWKCDELLMI
DTNGRVISYNSSIGYLSYLHIPLIINRVIDSQALIYoooooooooooooo
o
>C13
KSLMRFKCIRKSWCSIINSPSFVAKHLSNSADNKLSSSTCILLNRCQVHV
FPDKNWKQDVFWSMINRSIDSDEHNLHYDVEDLNIPFPMEDQDNVDLHGY
CNGIVCVIVGKNVLLCNPATGEFRQLPDSSLLLPLPKGRFGLETIFKGLG
FGYDCKAKEYKVVRIIENCDCEYSEGEESYYERILLPHTAEVYTMNANSW
KEIKIDVTSDTDPYCIPYSCSVYLKGFCYWFAMDNGEYIFSFDLGDELFH
IIELPSRKESGFKFYGLFLYNESITSYCSHYEESNSKLFEIWVooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
o
>C14
MSQVHESETPEDKVVEILSRLSPKSLMRFKCVHRSWCTIISSPSFVAKHL
SNTVDNKFSSFTCILFNRCQVHVFPDRSWKRDVFWSMINLSIDSDEHNLH
YDVEDRNIPFPIEVQDNVQLYGYCNGIVCVIVGENVLLCNPATREFKQLP
DSSLLLPLPMGKFGLETLFKGLGFGYDCKTKEYKVVRIIENCDCEYSDGK
ESYIERILLPYTAEVYTTAANSWKEIKIDTSSDTDPYCIPYSCSLYLKGF
CYWFANDNGEYIFSFDLGDEMFHRIELPFRRESDFKFCGLFLYNESVASY
CSCYEEDCKLVEIWVMDDYDGVKSSWTKLLTVGPFKDIESPLKFWKCDEV
LILSSYGKATSYNSSTGNLKYFHIPPIINWMIDYVETIVSVKoooooooo
o
>C15
KSLMRFKCIRKSWCTFINSPSFVAKYLSNSVHNKLSSSTCILLNRTQMHV
FPDQSWKYETLWSMMNLSNYSDEHNLHYDFKDLNIPFPTEDHHPVQIHSY
CNGIVCVITGKSVRILCNPTTREFRQLPASCLLLPSPPQGKFQLETIFEG
LGFGYDYKAKEYKVVQIIENCEYSDDERRYYHRIALPHTAEVYTTTANSW
KEIKIEISSKTYQCYGSEYLKGFCYWLANDGDEYILSFDLGDEIFHIIQL
PSKRESGFKFYNIFLCNESIASFCCCYDPRNEDSTLCEIWVMDooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
oooooooooooooooooooooooooooooooooooooooooooooooooo
o
CLUSTAL FORMAT for T-COFFEE Version_10.00.r1613 [http://www.tcoffee.org] [MODE:  ], CPU=0.00 sec, SCORE=100, Nseq=15, Len=638 

C1              --------------------------------------------------
C2              ----------MNESETPGDRVVEILSKLWPKSLMRFKCIRKSWCTLINSP
C3              ------------------------------KSLMRFKCIHKSWFSLINSL
C4              --------------ETPEDKVVEILSRLQPKSLMRFKCIHKSWCTLINSP
C5              -------MSQVRESETLEDRVVETLSRLPPKSLIRFKCIRKSWCTLINNP
C6              MWNKIFEMSQARESETLEDKVVQILSRLPPKSLMRFKCTRKSWCTLINSS
C7              ------------------------------------KCIRKSWCTLINSP
C8              -------MSLVRESEIPEDRVVEILPRLSPKSLLRFKCIRKSWCTLINSP
C9              --------------------------------------------------
C10             -------MTQVRESETPEDRVAEILSRLPPKSLMRFKCIRKSWYKVIKNP
C11             -------MSLVRESEIPEDRVVEILPRLSPKSLLRFKCIrKSWCTLINSP
C12             -------MSQVSESETPEDKVVEILSKLPPKSLMRFKCIRKSWCTIINSP
C13             ------------------------------KSLMRFKCIRKSWCSIINSP
C14             -------MSQVHESETPEDKVVEILSRLSPKSLMRFKCVHRSWCTIISSP
C15             ------------------------------KSLMRFKCIRKSWCTFINSP
                                                                  

C1              ---------------LSSSTCILLNRCQNHVFPDRSWKPEVFWSLINLSI
C2              SFVVKHLN-NSMDNKLSSSTCILVNRSQPHIFPDQNWKQEIFWSKINISI
C3              SFVGKHLS-NFVDKKLSSSTCILLNRSHAHIFPDQSWKQEVFWSMINFSI
C4              SFVAKHLN-NSMDNKLSSSTCILLNRSQAHIFPDQSWKQEVFWSTINLSI
C5              SFVAKHLN-NSMDNKLSSSTCILLSRSQAHVFPDNSWKPEVFWSLINLSI
C6              SFVAKHLS-NSIDNKLSSSTCILLNRSKMPVFLDKSWKYEILWSMIYLSI
C7              RFVAKHLN-NSTDNKLSSSTRILLHRSQMPIFPCDSWKREFFWSMINLSI
C8              SFVAKQLS-NSVDNKFSSSTCILLNRSQTHVFPDNSWKQEVFWSMINLSl
C9              --------------------------------------------------
C10             SFMAKHLSKNSVDNKFSSSTCILLHRSQMPVFPDRSWKREYFWSMINLSH
C11             SFVAKHLN-NSVDNKRSSSTCILLNRSQFHIFPDQSWKREVLWSMINLSS
C12             SFVAKHLS-NSVDNKFSSSTCILLNRSQVHVFPDKSWKHEVLWSMIKFFN
C13             SFVAKHLS-NSADNKLSSSTCILLNRCQVHVFPDKNWKQDVFWSMINRSI
C14             SFVAKHLS-NTVDNKFSSFTCILFNRCQVHVFPDRSWKRDVFWSMINLSI
C15             SFVAKYLS-NSVHNKLSSSTCILLNRTQMHVFPDQSWKYETLWSMMNLSN
                                                                  

C1              DSDDHNLHYDVEDL-NIP-CPLEGHDFVEIGGYCNGIVCVLAWKTLHWIY
C2              DSDEHNLHYDVVDL-NIP-FPLEDHDFVQIHGYCSGIVCVIVGKHF----
C3              DNDENNLHYDVEDL-NIP-FPLNDHDFVLIFGYCNGIVCVEAGKNV----
C4              DSDEHNLHYDVEDL-IIP-FPLEDHDFVLIFGYCNGIICVDAGKNV----
C5              DSDEHNLHYDVEDL-NIP-FPLEGHDFVQIEGYCNGIVCVIAGTSLYLIN
C6              DSDEHNHHYDVEDL-NIP-FPLEDHHPVQIHGYCNGIICVIAGKTV----
C7              DSDESNLHYDVEDLTNIPLLQWEDHHEVEIHGYCNGIVCVTVGEYF----
C8              DSDEHNLHYDVEDL-NIP-FPLEDHDYVLILGYCNGIVCVTAGKNI----
C9              --------------------------------------------------
C10             DSDKHNLYYDVEDL-NIQ-FPLEDHDHVSIHGYCNGIVCLIVGKNA----
C11             DSNVHNLHYDVKPL-NIP-FSRDDHNPVQIHGYCNGIVCLIEGDNV----
C12             DRISRTLYYDVEDL-NIP-FPRDDHQHVLIHGYCNGIVCVISGKNI----
C13             DSDEHNLHYDVEDL-NIP-FPMEDQDNVDLHGYCNGIVCVIVGKNV----
C14             DSDEHNLHYDVEDR-NIP-FPIEVQDNVQLYGYCNGIVCVIVGENV----
C15             YSDEHNLHYDFKDL-NIP-FPTEDHHPVQIHSYCNGIVCVITGKSV----
                                                                  

C1              VILCNPATGEFRQLPHSCLLQPSR-SRRKFELNTISTLLGFGYDCKAKEY
C2              -LLCNPATREFKQLPDSCLLLPT--AEGKFELDTTFEALGFGFDCKAKEY
C3              -LLCNPATREFRQLPDSCLLLPSP-PEGKFELETSFQALGFGYDCNAKEY
C4              -LLCNPATREFRQLPDSCLLLPP--PKGKFELETTFQALGFGYDCNSKEY
C5              VLLCNPATGKFRQLPPSCLLLPSR-PKGKFELESIFGGLGFGYDCKAKEY
C6              IILCNPGTREFRQLPDSCLLVPL--PKEKFQLETIFGGLGFGYDCKAKEY
C7              -FLCNPATGEFSQLPNSRLLLPLPGGKGKFGLETTVKGLGFGYDCKAKEY
C8              -LLCNPTTREFMRLPSSCLLLPSR-PKGKFELETVFRALGFGYDCKAKEY
C9              -----------------------------------------------KEY
C10             -VLYNPATRELKQLPDSCLLLPSP-PEGKFKLESTFQGMGFGYDSQAKEY
C11             -LLCNPSTREFRLLPNSCLLVPH--PEGKFQLETTFHGMGFGYDCKANEY
C12             -LLCNPATREFRQLPDSFLVLPSP-LSGKFELETDLGGLGFGYDCRAKDY
C13             -LLCNPATGEFRQLPDSSLLLPL--PKGRFGLETIFKGLGFGYDCKAKEY
C14             -LLCNPATREFKQLPDSSLLLPL--PMGKFGLETLFKGLGFGYDCKTKEY
C15             RILCNPTTREFRQLPASCLLLPSP-PQGKFQLETIFEGLGFGYDYKAKEY
                                                               ::*

C1              KVVQVIEN--CEYSDAEQYDYHRIALPHTAEVYTTTANSWREIKIDISSE
C2              KVVQIIEN--CEYSDDEQTFYHCTTLPHTAEVYTTAANSWKEIKIDISSK
C3              KVLRIIEN--CEYSDEERTFYHRIALPHTAELYTATANSWKEIKIDISSA
C4              KVVRIIEN--CEYSDDEQTFHHRIALPHTAEVYTTAANSWKEIKIDISSQ
C5              KVVQIIEN--CEYSDDQQYYYHRIALPHTAEVYTMAANSWREIKIDLSSE
C6              KVVQIIEN--CEYSNDERTFYHSIPLPHTAEVYTIAANSWKEIKIDISTK
C7              KVVRIIENYDCEYSDGEETYIKHTALPHTAEVYTTTANSWKEIQINISSK
C8              KVVQIIEN--SEYSDDERTYYHRIPLPHTAEVYTTAANSWREIKIDISTK
C9              KVVQIIEN--CEYSDDQQYYYHRIALPHTAEVYTMAANSWRVIKIDISSE
C10             KVVKIIEN--CEYSDDMRTFSHRIALPHTAEVYVMTTNSWRVIEIEISSD
C11             KVVQIVEN--CEYSDDEQTYQHCIAYPYTAEVYTTAANFWKEIKIDISSS
C12             KVVRIIEN--CEYSDDERTYYNRIPLPHTSEVYTMATNSWKEIKIDISRK
C13             KVVRIIENCDCEYSEGEESYYERILLPHTAEVYTMNANSWKEIKIDVTSD
C14             KVVRIIENCDCEYSDGKESYIERILLPYTAEVYTTAANSWKEIKIDTSSD
C15             KVVQIIEN--CEYSDDERRYYHRIALPHTAEVYTTTANSWKEIKIEISSK
                **::::**  .***:  .   .    *:*:*:*.  :* *: *:*: :  

C1              T---YC--YTCSVYLNGFCYWIATDEEDFILSFDLGDEIFHRIQLPSRRD
C2              T---YS--WSCSVYLKGFCYWYATDDEEYVLSFDLGDETFHRIQLPSRGV
C3              T---YS--CSRSVFLKGFCYWYATDGEEYVLSFDLGDDTFHIIQLPPRRE
C4              T---YH--CSCSVYLNGFCYWFASDSEEYILSFYLGDETFHIIQLPSRRE
C5              T---FH--CSYSVYLKGFCYWLATNGEKYILSFDFGDKVFHRIQLPSRRE
C6              T---YP--SSCSVYLKGFCYWFASDGEECILSFDLGDEIFHRIQLPSRRE
C7              ILSFYSYPYSCSLYLKGFCYWLSSDDEEYVFSFDLGDEIFDRIELPSRRE
C8              T---YS--CSCQVYLKGFCYWYATDAEEYILSFDLGDEIFHRIQLPSRRE
C9              T---YH--YSSSVYLNGFFYWFAIDGEKYVLSFDLGDEIFHRIQLPSRKE
C10             T---YN--CSCSVYLKGFCYWFASDDEEYILSFDLGDEIFHRIQLPYRKE
C11             T---HP--YPFSVYLKGFCYWFATDGEECILSFDLGDEIFHRIQLPSKIE
C12             T---YP--CSCSVYLKGFCYWFTRDGEEFILSFDLGDERFHRIQLPSRRE
C13             T-DPYCIPYSCSVYLKGFCYWFAMDNGEYIFSFDLGDELFHIIELPSRKE
C14             T-DPYCIPYSCSLYLKGFCYWFANDNGEYIFSFDLGDEMFHRIELPFRRE
C15             T---YQ--CYGSEYLKGFCYWLANDGDEYILSFDLGDEIFHIIQLPSKRE
                    .      . :*:** ** : :  . ::** :**. *. *:** :  

C1              SDFKFSNLFLCNKSIASFGYCCNPSDEDSToooo---ooooooooooooo
C2              SGFTFFYIFLCNGSLASFCSRYDGS-GDSQSCEI---WV-----------
C3              SGFRFYYIFLRNESLASFCSRYDRS-EDSESCEI---WV-----------
C4              SGFTFDYIFLRNESLASFCSPYNPS-EDSKLFEI---WV-----------
C5              SDFEFSNLFLCNNSMASFFSCCDPSDEDSTLCEI---WV-----------
C6              SSFKFYDIFLYNESITSYCSHYDPS-DDSKLFEI---WV-----------
C7              SGFKLDGIFLYNESITYYCTSYE-E--CSRLFEI---WV-----------
C8              SGFKFYYIFLCNESIASFCSCYoooooooooooo---oo-----------
C9              SDFEFSNIFLCNKSIASFCSRCDPSDEDSTLCEI---WV-----------
C10             SGFLFYNLFLYNESIASFCSHYDKS-DNSGILEILEIWV-----------
C11             SGFNFCGLFLYNESITSYCCRYDPS-EDSKLFEI---WV-----------
C12             SGLEFYYIFLCNESIASFCSLYDRS-EDSKLCEI---WV-----------
C13             SGFKFYGLFLYNESITSYCSHYEES--NSKLFEI---WV-----------
C14             SDFKFCGLFLYNESVASYCSCYE---EDCKLVEI---WV-----------
C15             SGFKFYNIFLCNESIASFCCCYDPRNEDSTLCEI---WV-----------
                *.: :  :** * *:: :                                

C1              oooooooooooooooooooooooooooooooooooooooooooooooooo
C2              -------------------MGDYGKVKSSWTKLLTIESLQGIEKPLTFWK
C3              -------------------MDDYDRVKSSWTKLLTIGPLQGIK