--- EXPERIMENT NOTES --- EXPERIMENT PROPERTIES #Fri Nov 03 22:34:30 WET 2017 codeml.models=0 1 2 3 7 8 mrbayes.mpich= mrbayes.ngen=1000000 tcoffee.alignMethod=MUSCLE tcoffee.params= tcoffee.maxSeqs=0 codeml.bin=codeml mrbayes.tburnin=2500 codeml.dir= input.sequences= mrbayes.pburnin=2500 mrbayes.bin=mb_adops tcoffee.bin=t_coffee_ADOPS mrbayes.dir=/usr/bin/ tcoffee.dir= tcoffee.minScore=3 input.fasta= input.names= mrbayes.params= codeml.params= --- PSRF SUMMARY Estimated marginal likelihoods for runs sampled in files "/opt/ADOPS1/revmuscle/S25falta/batch/allfiles/mrbayes/input.fasta.fasta.mrb.run1.p" and "/opt/ADOPS1/revmuscle/S25falta/batch/allfiles/mrbayes/input.fasta.fasta.mrb.run2.p": (Use the harmonic mean for Bayes factor comparisons of models) (Values are saved to the file /opt/ADOPS1/revmuscle/S25falta/batch/allfiles/mrbayes/input.fasta.fasta.mrb.lstat) Run Arithmetic mean Harmonic mean -------------------------------------- 1 -7042.75 -7064.12 2 -7043.10 -7065.66 -------------------------------------- TOTAL -7042.91 -7065.16 -------------------------------------- Model parameter summaries over the runs sampled in files "/opt/ADOPS1/revmuscle/S25falta/batch/allfiles/mrbayes/input.fasta.fasta.mrb.run1.p" and "/opt/ADOPS1/revmuscle/S25falta/batch/allfiles/mrbayes/input.fasta.fasta.mrb.run2.p": Summaries are based on a total of 3002 samples from 2 runs. Each run produced 2001 samples of which 1501 samples were included. Parameter summaries saved to file "/opt/ADOPS1/revmuscle/S25falta/batch/allfiles/mrbayes/input.fasta.fasta.mrb.pstat". 95% HPD Interval -------------------- Parameter Mean Variance Lower Upper Median min ESS* avg ESS PSRF+ ------------------------------------------------------------------------------------------------------ TL{all} 1.331016 0.003233 1.226320 1.443893 1.329765 1298.93 1395.16 1.000 r(A<->C){all} 0.117474 0.000158 0.092901 0.142302 0.117121 847.48 939.43 1.000 r(A<->G){all} 0.297363 0.000379 0.258844 0.334796 0.297474 750.19 872.46 1.000 r(A<->T){all} 0.078046 0.000068 0.062948 0.095105 0.077873 1153.77 1174.83 1.000 r(C<->G){all} 0.163156 0.000263 0.134256 0.196607 0.162620 663.76 853.84 1.000 r(C<->T){all} 0.260710 0.000330 0.225974 0.295316 0.260394 906.07 911.85 1.001 r(G<->T){all} 0.083251 0.000089 0.064139 0.100506 0.082960 992.18 1020.01 1.000 pi(A){all} 0.301392 0.000122 0.278863 0.322302 0.301282 856.66 920.63 1.001 pi(C){all} 0.175863 0.000081 0.158631 0.193971 0.175793 1076.44 1093.34 1.000 pi(G){all} 0.189692 0.000085 0.171870 0.207324 0.189621 989.99 1044.81 1.001 pi(T){all} 0.333053 0.000128 0.310984 0.355661 0.332719 776.17 877.57 1.001 alpha{1,2} 0.750422 0.013312 0.546611 0.979599 0.735035 1109.70 1259.81 1.000 alpha{3} 1.744012 0.198230 1.012189 2.626343 1.665629 1147.07 1262.52 1.000 pinvar{all} 0.045311 0.001303 0.000011 0.116443 0.036826 1088.31 1180.89 1.001 ------------------------------------------------------------------------------------------------------ * Convergence diagnostic (ESS = Estimated Sample Size); min and avg values correspond to minimal and average ESS among runs. ESS value below 100 may indicate that the parameter is undersampled. + Convergence diagnostic (PSRF = Potential Scale Reduction Factor; Gelman and Rubin, 1992) should approach 1.0 as runs converge. Setting sumt conformat to Simple --- CODEML SUMMARY Model 1: NearlyNeutral -2227.921827 Model 2: PositiveSelection -2204.837837 Model 0: one-ratio -2280.446087 Model 3: discrete -2204.797246 Model 7: beta -2231.552526 Model 8: beta&w>1 -2206.079964 Model 0 vs 1 105.04851999999937 Model 2 vs 1 46.16798000000017 Additional information for M1 vs M2: Naive Empirical Bayes (NEB) analysis Positively selected sites (*: P>95%; **: P>99%) (amino acids refer to 1st sequence: S25_SFBB1) Pr(w>1) post mean +- SE for w 19 Q 0.935 4.532 36 T 0.866 4.269 51 E 0.981* 4.704 54 C 1.000** 4.776 70 T 1.000** 4.776 72 E 0.988* 4.731 100 K 0.867 4.275 117 C 0.973* 4.673 Bayes Empirical Bayes (BEB) analysis (Yang, Wong & Nielsen 2005. Mol. Biol. Evol. 22:1107-1118) Positively selected sites (*: P>95%; **: P>99%) (amino acids refer to 1st sequence: S25_SFBB1) Pr(w>1) post mean +- SE for w 19 Q 0.922 4.647 +- 1.324 36 T 0.826 4.219 +- 1.644 51 E 0.971* 4.830 +- 1.047 54 C 1.000** 4.959 +- 0.836 70 T 1.000** 4.958 +- 0.837 72 E 0.985* 4.901 +- 0.956 100 K 0.822 4.194 +- 1.646 117 C 0.948 4.716 +- 1.163 Model 8 vs 7 50.94512399999985 Additional information for M7 vs M8: Naive Empirical Bayes (NEB) analysis Positively selected sites (*: P>95%; **: P>99%) (amino acids refer to 1st sequence: S25_SFBB1) Pr(w>1) post mean +- SE for w 19 Q 0.954* 4.173 36 T 0.909 4.019 51 E 0.988* 4.289 54 C 1.000** 4.329 70 T 1.000** 4.328 72 E 0.992** 4.301 100 K 0.913 4.033 117 C 0.985* 4.277 Bayes Empirical Bayes (BEB) analysis (Yang, Wong & Nielsen 2005. Mol. Biol. Evol. 22:1107-1118) Positively selected sites (*: P>95%; **: P>99%) (amino acids refer to 1st sequence: S25_SFBB1) Pr(w>1) post mean +- SE for w 19 Q 0.946 4.221 +- 1.112 36 T 0.882 3.962 +- 1.339 51 E 0.984* 4.354 +- 0.904 54 C 1.000** 4.418 +- 0.800 70 T 1.000** 4.418 +- 0.801 72 E 0.990** 4.384 +- 0.867 100 K 0.884 3.960 +- 1.329 117 C 0.973* 4.306 +- 0.955
>C1 LSSSTCILLNRCQNHVFPDRSWKPEVFWSLINLSIDSDDHNLHYDVEDLN IPCPLEGHDFVEIGGYCNGIVCVLAWKTLHWIYVILCNPATGEFRQLPHS CLLQPSRSRRKFELNTISTLLGFGYDCKAKEYKVVQVIENCEYSDAEQYD YHRIALPHTAEVYTTTANSWREIKIDISSETYCYTCSVYLNGFCYWIATD EEDFILSFDLGDEIFHRIQLPSRRDSDFKFSNLFLCNKSIASFGYCCNPS DEDSTooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo o >C2 MNESETPGDRVVEILSKLWPKSLMRFKCIRKSWCTLINSPSFVVKHLNNS MDNKLSSSTCILVNRSQPHIFPDQNWKQEIFWSKINISIDSDEHNLHYDV VDLNIPFPLEDHDFVQIHGYCSGIVCVIVGKHFLLCNPATREFKQLPDSC LLLPTAEGKFELDTTFEALGFGFDCKAKEYKVVQIIENCEYSDDEQTFYH CTTLPHTAEVYTTAANSWKEIKIDISSKTYSWSCSVYLKGFCYWYATDDE EYVLSFDLGDETFHRIQLPSRGVSGFTFFYIFLCNGSLASFCSRYDGSGD SQSCEIWVMGDYGKVKSSWTKLLTIESLQGIEKPLTFWKSDELLMLASNG KATSYNSSSGNLKYVHIPPILNKVVDFQALIYVESIVSLKoooooooooo o >C3 KSLMRFKCIHKSWFSLINSLSFVGKHLSNFVDKKLSSSTCILLNRSHAHI FPDQSWKQEVFWSMINFSIDNDENNLHYDVEDLNIPFPLNDHDFVLIFGY CNGIVCVEAGKNVLLCNPATREFRQLPDSCLLLPSPPEGKFELETSFQAL GFGYDCNAKEYKVLRIIENCEYSDEERTFYHRIALPHTAELYTATANSWK EIKIDISSATYSCSRSVFLKGFCYWYATDGEEYVLSFDLGDDTFHIIQLP PRRESGFRFYYIFLRNESLASFCSRYDRSEDSESCEIWVMDDYDRVKSSW TKLLTIGPLQGIKKPLTFWKSDEVLMLDSDGRATSYNSNTRNLKYLHIPP ILKRVVDFEVLIYVKSoooooooooooooooooooooooooooooooooo o >C4 ETPEDKVVEILSRLQPKSLMRFKCIHKSWCTLINSPSFVAKHLNNSMDNK LSSSTCILLNRSQAHIFPDQSWKQEVFWSTINLSIDSDEHNLHYDVEDLI IPFPLEDHDFVLIFGYCNGIICVDAGKNVLLCNPATREFRQLPDSCLLLP PPKGKFELETTFQALGFGYDCNSKEYKVVRIIENCEYSDDEQTFHHRIAL PHTAEVYTTAANSWKEIKIDISSQTYHCSCSVYLNGFCYWFASDSEEYIL SFYLGDETFHIIQLPSRRESGFTFDYIFLRNESLASFCSPYNPSEDSKLF EIWVMDDYDGVKSSWTKLLTVGPFKGIEYPLTLWKCDELLMLASDGRATS YNSSTGNLKYLHIPPILNKVVDFEGLIYVKSIVPoooooooooooooooo o >C5 MSQVRESETLEDRVVETLSRLPPKSLIRFKCIRKSWCTLINNPSFVAKHL NNSMDNKLSSSTCILLSRSQAHVFPDNSWKPEVFWSLINLSIDSDEHNLH YDVEDLNIPFPLEGHDFVQIEGYCNGIVCVIAGTSLYLINVLLCNPATGK FRQLPPSCLLLPSRPKGKFELESIFGGLGFGYDCKAKEYKVVQIIENCEY SDDQQYYYHRIALPHTAEVYTMAANSWREIKIDLSSETFHCSYSVYLKGF CYWLATNGEKYILSFDFGDKVFHRIQLPSRRESDFEFSNLFLCNNSMASF FSCCDPSDEDSTLCEIWVoooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo o >C6 MWNKIFEMSQARESETLEDKVVQILSRLPPKSLMRFKCTRKSWCTLINSS SFVAKHLSNSIDNKLSSSTCILLNRSKMPVFLDKSWKYEILWSMIYLSID SDEHNHHYDVEDLNIPFPLEDHHPVQIHGYCNGIICVIAGKTVIILCNPG TREFRQLPDSCLLVPLPKEKFQLETIFGGLGFGYDCKAKEYKVVQIIENC EYSNDERTFYHSIPLPHTAEVYTIAANSWKEIKIDISTKTYPSSCSVYLK GFCYWFASDGEECILSFDLGDEIFHRIQLPSRRESSFKFYDIFLYNESIT SYCSHYDPSDDSKLFEIWVMDDYDGSKSSWTKLLTVGPFKGIEYPLALWK CDELLMLASNGRAISYNSSTGNLKYLHIPPIINEVIDFEALSYVESIVPI K >C7 KCIRKSWCTLINSPRFVAKHLNNSTDNKLSSSTRILLHRSQMPIFPCDSW KREFFWSMINLSIDSDESNLHYDVEDLTNIPLLQWEDHHEVEIHGYCNGI VCVTVGEYFFLCNPATGEFSQLPNSRLLLPLPGGKGKFGLETTVKGLGFG YDCKAKEYKVVRIIENYDCEYSDGEETYIKHTALPHTAEVYTTTANSWKE IQINISSKILSFYSYPYSCSLYLKGFCYWLSSDDEEYVFSFDLGDEIFDR IELPSRRESGFKLDGIFLYNESITYYCTSYEECSRLFEIWVMDNYDGVKS SWTKoooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo o >C8 MSLVRESEIPEDRVVEILPRLSPKSLLRFKCIRKSWCTLINSPSFVAKQL SNSVDNKFSSSTCILLNRSQTHVFPDNSWKQEVFWSMINLSlDSDEHNLH YDVEDLNIPFPLEDHDYVLILGYCNGIVCVTAGKNILLCNPTTREFMRLP SSCLLLPSRPKGKFELETVFRALGFGYDCKAKEYKVVQIIENSEYSDDER TYYHRIPLPHTAEVYTTAANSWREIKIDISTKTYSCSCQVYLKGFCYWYA TDAEEYILSFDLGDEIFHRIQLPSRRESGFKFYYIFLCNESIASFCSCYo oooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo o >C9 KEYKVVQIIENCEYSDDQQYYYHRIALPHTAEVYTMAANSWRVIKIDISS ETYHYSSSVYLNGFFYWFAIDGEKYVLSFDLGDEIFHRIQLPSRKESDFE FSNIFLCNKSIASFCSRCDPSDEDSTLCEIWVMDDYDGVDRSWTKLLTFG PLKDIENPFTFWKTDELLMVAAGGRATTYNFSTGNLNYLHIPPILNEVRD FEALIYVESIVPVKoooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo o >C10 MTQVRESETPEDRVAEILSRLPPKSLMRFKCIRKSWYKVIKNPSFMAKHL SKNSVDNKFSSSTCILLHRSQMPVFPDRSWKREYFWSMINLSHDSDKHNL YYDVEDLNIQFPLEDHDHVSIHGYCNGIVCLIVGKNAVLYNPATRELKQL PDSCLLLPSPPEGKFKLESTFQGMGFGYDSQAKEYKVVKIIENCEYSDDM RTFSHRIALPHTAEVYVMTTNSWRVIEIEISSDTYNCSCSVYLKGFCYWF ASDDEEYILSFDLGDEIFHRIQLPYRKESGFLFYNLFLYNESIASFCSHY DKSDNSGILEILEIWVMDDCDGVKSSWTKLLTLGPFKDNENLLTFWKSDE LLMVTSDKKTISYNSSTGNLKYIHIPPIINKVoooooooooooooooooo o >C11 MSLVRESEIPEDRVVEILPRLSPKSLLRFKCIrKSWCTLINSPSFVAKHL NNSVDNKRSSSTCILLNRSQFHIFPDQSWKREVLWSMINLSSDSNVHNLH YDVKPLNIPFSRDDHNPVQIHGYCNGIVCLIEGDNVLLCNPSTREFRLLP NSCLLVPHPEGKFQLETTFHGMGFGYDCKANEYKVVQIVENCEYSDDEQT YQHCIAYPYTAEVYTTAANFWKEIKIDISSSTHPYPFSVYLKGFCYWFAT DGEECILSFDLGDEIFHRIQLPSKIESGFNFCGLFLYNESITSYCCRYDP SEDSKLFEIWVMDooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo o >C12 MSQVSESETPEDKVVEILSKLPPKSLMRFKCIRKSWCTIINSPSFVAKHL SNSVDNKFSSSTCILLNRSQVHVFPDKSWKHEVLWSMIKFFNDRISRTLY YDVEDLNIPFPRDDHQHVLIHGYCNGIVCVISGKNILLCNPATREFRQLP DSFLVLPSPLSGKFELETDLGGLGFGYDCRAKDYKVVRIIENCEYSDDER TYYNRIPLPHTSEVYTMATNSWKEIKIDISRKTYPCSCSVYLKGFCYWFT RDGEEFILSFDLGDERFHRIQLPSRRESGLEFYYIFLCNESIASFCSLYD RSEDSKLCEIWVMDDYDGVKSSWTKLLVAGPFKGIEKPLTLWKCDELLMI DTNGRVISYNSSIGYLSYLHIPLIINRVIDSQALIYoooooooooooooo o >C13 KSLMRFKCIRKSWCSIINSPSFVAKHLSNSADNKLSSSTCILLNRCQVHV FPDKNWKQDVFWSMINRSIDSDEHNLHYDVEDLNIPFPMEDQDNVDLHGY CNGIVCVIVGKNVLLCNPATGEFRQLPDSSLLLPLPKGRFGLETIFKGLG FGYDCKAKEYKVVRIIENCDCEYSEGEESYYERILLPHTAEVYTMNANSW KEIKIDVTSDTDPYCIPYSCSVYLKGFCYWFAMDNGEYIFSFDLGDELFH IIELPSRKESGFKFYGLFLYNESITSYCSHYEESNSKLFEIWVooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo o >C14 MSQVHESETPEDKVVEILSRLSPKSLMRFKCVHRSWCTIISSPSFVAKHL SNTVDNKFSSFTCILFNRCQVHVFPDRSWKRDVFWSMINLSIDSDEHNLH YDVEDRNIPFPIEVQDNVQLYGYCNGIVCVIVGENVLLCNPATREFKQLP DSSLLLPLPMGKFGLETLFKGLGFGYDCKTKEYKVVRIIENCDCEYSDGK ESYIERILLPYTAEVYTTAANSWKEIKIDTSSDTDPYCIPYSCSLYLKGF CYWFANDNGEYIFSFDLGDEMFHRIELPFRRESDFKFCGLFLYNESVASY CSCYEEDCKLVEIWVMDDYDGVKSSWTKLLTVGPFKDIESPLKFWKCDEV LILSSYGKATSYNSSTGNLKYFHIPPIINWMIDYVETIVSVKoooooooo o >C15 KSLMRFKCIRKSWCTFINSPSFVAKYLSNSVHNKLSSSTCILLNRTQMHV FPDQSWKYETLWSMMNLSNYSDEHNLHYDFKDLNIPFPTEDHHPVQIHSY CNGIVCVITGKSVRILCNPTTREFRQLPASCLLLPSPPQGKFQLETIFEG LGFGYDYKAKEYKVVQIIENCEYSDDERRYYHRIALPHTAEVYTTTANSW KEIKIEISSKTYQCYGSEYLKGFCYWLANDGDEYILSFDLGDEIFHIIQL PSKRESGFKFYNIFLCNESIASFCCCYDPRNEDSTLCEIWVMDooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooooooooooooooo o CLUSTAL FORMAT for T-COFFEE Version_10.00.r1613 [http://www.tcoffee.org] [MODE: ], CPU=0.00 sec, SCORE=100, Nseq=15, Len=638 C1 -------------------------------------------------- C2 ----------MNESETPGDRVVEILSKLWPKSLMRFKCIRKSWCTLINSP C3 ------------------------------KSLMRFKCIHKSWFSLINSL C4 --------------ETPEDKVVEILSRLQPKSLMRFKCIHKSWCTLINSP C5 -------MSQVRESETLEDRVVETLSRLPPKSLIRFKCIRKSWCTLINNP C6 MWNKIFEMSQARESETLEDKVVQILSRLPPKSLMRFKCTRKSWCTLINSS C7 ------------------------------------KCIRKSWCTLINSP C8 -------MSLVRESEIPEDRVVEILPRLSPKSLLRFKCIRKSWCTLINSP C9 -------------------------------------------------- C10 -------MTQVRESETPEDRVAEILSRLPPKSLMRFKCIRKSWYKVIKNP C11 -------MSLVRESEIPEDRVVEILPRLSPKSLLRFKCIrKSWCTLINSP C12 -------MSQVSESETPEDKVVEILSKLPPKSLMRFKCIRKSWCTIINSP C13 ------------------------------KSLMRFKCIRKSWCSIINSP C14 -------MSQVHESETPEDKVVEILSRLSPKSLMRFKCVHRSWCTIISSP C15 ------------------------------KSLMRFKCIRKSWCTFINSP C1 ---------------LSSSTCILLNRCQNHVFPDRSWKPEVFWSLINLSI C2 SFVVKHLN-NSMDNKLSSSTCILVNRSQPHIFPDQNWKQEIFWSKINISI C3 SFVGKHLS-NFVDKKLSSSTCILLNRSHAHIFPDQSWKQEVFWSMINFSI C4 SFVAKHLN-NSMDNKLSSSTCILLNRSQAHIFPDQSWKQEVFWSTINLSI C5 SFVAKHLN-NSMDNKLSSSTCILLSRSQAHVFPDNSWKPEVFWSLINLSI C6 SFVAKHLS-NSIDNKLSSSTCILLNRSKMPVFLDKSWKYEILWSMIYLSI C7 RFVAKHLN-NSTDNKLSSSTRILLHRSQMPIFPCDSWKREFFWSMINLSI C8 SFVAKQLS-NSVDNKFSSSTCILLNRSQTHVFPDNSWKQEVFWSMINLSl C9 -------------------------------------------------- C10 SFMAKHLSKNSVDNKFSSSTCILLHRSQMPVFPDRSWKREYFWSMINLSH C11 SFVAKHLN-NSVDNKRSSSTCILLNRSQFHIFPDQSWKREVLWSMINLSS C12 SFVAKHLS-NSVDNKFSSSTCILLNRSQVHVFPDKSWKHEVLWSMIKFFN C13 SFVAKHLS-NSADNKLSSSTCILLNRCQVHVFPDKNWKQDVFWSMINRSI C14 SFVAKHLS-NTVDNKFSSFTCILFNRCQVHVFPDRSWKRDVFWSMINLSI C15 SFVAKYLS-NSVHNKLSSSTCILLNRTQMHVFPDQSWKYETLWSMMNLSN C1 DSDDHNLHYDVEDL-NIP-CPLEGHDFVEIGGYCNGIVCVLAWKTLHWIY C2 DSDEHNLHYDVVDL-NIP-FPLEDHDFVQIHGYCSGIVCVIVGKHF---- C3 DNDENNLHYDVEDL-NIP-FPLNDHDFVLIFGYCNGIVCVEAGKNV---- C4 DSDEHNLHYDVEDL-IIP-FPLEDHDFVLIFGYCNGIICVDAGKNV---- C5 DSDEHNLHYDVEDL-NIP-FPLEGHDFVQIEGYCNGIVCVIAGTSLYLIN C6 DSDEHNHHYDVEDL-NIP-FPLEDHHPVQIHGYCNGIICVIAGKTV---- C7 DSDESNLHYDVEDLTNIPLLQWEDHHEVEIHGYCNGIVCVTVGEYF---- C8 DSDEHNLHYDVEDL-NIP-FPLEDHDYVLILGYCNGIVCVTAGKNI---- C9 -------------------------------------------------- C10 DSDKHNLYYDVEDL-NIQ-FPLEDHDHVSIHGYCNGIVCLIVGKNA---- C11 DSNVHNLHYDVKPL-NIP-FSRDDHNPVQIHGYCNGIVCLIEGDNV---- C12 DRISRTLYYDVEDL-NIP-FPRDDHQHVLIHGYCNGIVCVISGKNI---- C13 DSDEHNLHYDVEDL-NIP-FPMEDQDNVDLHGYCNGIVCVIVGKNV---- C14 DSDEHNLHYDVEDR-NIP-FPIEVQDNVQLYGYCNGIVCVIVGENV---- C15 YSDEHNLHYDFKDL-NIP-FPTEDHHPVQIHSYCNGIVCVITGKSV---- C1 VILCNPATGEFRQLPHSCLLQPSR-SRRKFELNTISTLLGFGYDCKAKEY C2 -LLCNPATREFKQLPDSCLLLPT--AEGKFELDTTFEALGFGFDCKAKEY C3 -LLCNPATREFRQLPDSCLLLPSP-PEGKFELETSFQALGFGYDCNAKEY C4 -LLCNPATREFRQLPDSCLLLPP--PKGKFELETTFQALGFGYDCNSKEY C5 VLLCNPATGKFRQLPPSCLLLPSR-PKGKFELESIFGGLGFGYDCKAKEY C6 IILCNPGTREFRQLPDSCLLVPL--PKEKFQLETIFGGLGFGYDCKAKEY C7 -FLCNPATGEFSQLPNSRLLLPLPGGKGKFGLETTVKGLGFGYDCKAKEY C8 -LLCNPTTREFMRLPSSCLLLPSR-PKGKFELETVFRALGFGYDCKAKEY C9 -----------------------------------------------KEY C10 -VLYNPATRELKQLPDSCLLLPSP-PEGKFKLESTFQGMGFGYDSQAKEY C11 -LLCNPSTREFRLLPNSCLLVPH--PEGKFQLETTFHGMGFGYDCKANEY C12 -LLCNPATREFRQLPDSFLVLPSP-LSGKFELETDLGGLGFGYDCRAKDY C13 -LLCNPATGEFRQLPDSSLLLPL--PKGRFGLETIFKGLGFGYDCKAKEY C14 -LLCNPATREFKQLPDSSLLLPL--PMGKFGLETLFKGLGFGYDCKTKEY C15 RILCNPTTREFRQLPASCLLLPSP-PQGKFQLETIFEGLGFGYDYKAKEY ::* C1 KVVQVIEN--CEYSDAEQYDYHRIALPHTAEVYTTTANSWREIKIDISSE C2 KVVQIIEN--CEYSDDEQTFYHCTTLPHTAEVYTTAANSWKEIKIDISSK C3 KVLRIIEN--CEYSDEERTFYHRIALPHTAELYTATANSWKEIKIDISSA C4 KVVRIIEN--CEYSDDEQTFHHRIALPHTAEVYTTAANSWKEIKIDISSQ C5 KVVQIIEN--CEYSDDQQYYYHRIALPHTAEVYTMAANSWREIKIDLSSE C6 KVVQIIEN--CEYSNDERTFYHSIPLPHTAEVYTIAANSWKEIKIDISTK C7 KVVRIIENYDCEYSDGEETYIKHTALPHTAEVYTTTANSWKEIQINISSK C8 KVVQIIEN--SEYSDDERTYYHRIPLPHTAEVYTTAANSWREIKIDISTK C9 KVVQIIEN--CEYSDDQQYYYHRIALPHTAEVYTMAANSWRVIKIDISSE C10 KVVKIIEN--CEYSDDMRTFSHRIALPHTAEVYVMTTNSWRVIEIEISSD C11 KVVQIVEN--CEYSDDEQTYQHCIAYPYTAEVYTTAANFWKEIKIDISSS C12 KVVRIIEN--CEYSDDERTYYNRIPLPHTSEVYTMATNSWKEIKIDISRK C13 KVVRIIENCDCEYSEGEESYYERILLPHTAEVYTMNANSWKEIKIDVTSD C14 KVVRIIENCDCEYSDGKESYIERILLPYTAEVYTTAANSWKEIKIDTSSD C15 KVVQIIEN--CEYSDDERRYYHRIALPHTAEVYTTTANSWKEIKIEISSK **::::** .***: . . *:*:*:*. :* *: *:*: : C1 T---YC--YTCSVYLNGFCYWIATDEEDFILSFDLGDEIFHRIQLPSRRD C2 T---YS--WSCSVYLKGFCYWYATDDEEYVLSFDLGDETFHRIQLPSRGV C3 T---YS--CSRSVFLKGFCYWYATDGEEYVLSFDLGDDTFHIIQLPPRRE C4 T---YH--CSCSVYLNGFCYWFASDSEEYILSFYLGDETFHIIQLPSRRE C5 T---FH--CSYSVYLKGFCYWLATNGEKYILSFDFGDKVFHRIQLPSRRE C6 T---YP--SSCSVYLKGFCYWFASDGEECILSFDLGDEIFHRIQLPSRRE C7 ILSFYSYPYSCSLYLKGFCYWLSSDDEEYVFSFDLGDEIFDRIELPSRRE C8 T---YS--CSCQVYLKGFCYWYATDAEEYILSFDLGDEIFHRIQLPSRRE C9 T---YH--YSSSVYLNGFFYWFAIDGEKYVLSFDLGDEIFHRIQLPSRKE C10 T---YN--CSCSVYLKGFCYWFASDDEEYILSFDLGDEIFHRIQLPYRKE C11 T---HP--YPFSVYLKGFCYWFATDGEECILSFDLGDEIFHRIQLPSKIE C12 T---YP--CSCSVYLKGFCYWFTRDGEEFILSFDLGDERFHRIQLPSRRE C13 T-DPYCIPYSCSVYLKGFCYWFAMDNGEYIFSFDLGDELFHIIELPSRKE C14 T-DPYCIPYSCSLYLKGFCYWFANDNGEYIFSFDLGDEMFHRIELPFRRE C15 T---YQ--CYGSEYLKGFCYWLANDGDEYILSFDLGDEIFHIIQLPSKRE . . :*:** ** : : . ::** :**. *. *:** : C1 SDFKFSNLFLCNKSIASFGYCCNPSDEDSToooo---ooooooooooooo C2 SGFTFFYIFLCNGSLASFCSRYDGS-GDSQSCEI---WV----------- C3 SGFRFYYIFLRNESLASFCSRYDRS-EDSESCEI---WV----------- C4 SGFTFDYIFLRNESLASFCSPYNPS-EDSKLFEI---WV----------- C5 SDFEFSNLFLCNNSMASFFSCCDPSDEDSTLCEI---WV----------- C6 SSFKFYDIFLYNESITSYCSHYDPS-DDSKLFEI---WV----------- C7 SGFKLDGIFLYNESITYYCTSYE-E--CSRLFEI---WV----------- C8 SGFKFYYIFLCNESIASFCSCYoooooooooooo---oo----------- C9 SDFEFSNIFLCNKSIASFCSRCDPSDEDSTLCEI---WV----------- C10 SGFLFYNLFLYNESIASFCSHYDKS-DNSGILEILEIWV----------- C11 SGFNFCGLFLYNESITSYCCRYDPS-EDSKLFEI---WV----------- C12 SGLEFYYIFLCNESIASFCSLYDRS-EDSKLCEI---WV----------- C13 SGFKFYGLFLYNESITSYCSHYEES--NSKLFEI---WV----------- C14 SDFKFCGLFLYNESVASYCSCYE---EDCKLVEI---WV----------- C15 SGFKFYNIFLCNESIASFCCCYDPRNEDSTLCEI---WV----------- *.: : :** * *:: : C1 oooooooooooooooooooooooooooooooooooooooooooooooooo C2 -------------------MGDYGKVKSSWTKLLTIESLQGIEKPLTFWK C3 -------------------MDDYDRVKSSWTKLLTIGPLQGIK